Which of the following is a first-generation cephalosporin commonly used in ocular infections?

• A. Keflex
• B. Bacitracin
• C. Ciprofloxacin
• D. Azithromycin

Answer: (A)

First-generation cephalosporins are chosen for uncomplicated ocular surface infections because they primarily cover gram-positive cocci such as Staphylococcus and Streptococcus, with reliable oral absorption when systemic therapy is appropriate. Keflex (cephalexin) fits this class and has the typical spectrum of a first-generation cephalosporin, making it a common choice for treating mild ocular infections that involve these organisms. The other drugs listed are not first-generation cephalosporins: Bacitracin is a topical antibiotic active mainly against gram-positive bacteria but is not a cephalosporin; Ciprofloxacin is a fluoroquinolone with broad gram-negative and gram-positive coverage, not a first-generation cephalosporin; Azithromycin is a macrolide used for certain ocular infections but also not a cephalosporin. Therefore, Keflex is the correct option.