Which ocular sign is associated with MAOI use as referenced by the mnemonic?

• A. Conjunctival injection
• B. Nystagmus
• C. Mydriasis
• D. Ptosis

Answer: (B)

Nystagmus is the ocular sign tied to MAOI use in the mnemonic because these drugs act on central neurotransmitter systems and can disrupt the neural circuits that control eye movements. Monoamine oxidase inhibitors raise levels of monoamines in the brain, which can affect the vestibulo-ocular reflex and cerebellar pathways that coordinate smooth pursuit and gaze stability. This can manifest as involuntary, rhythmic eye movements—nystagmus.

Conjunctival injection is more about surface irritation or inflammation of the eye rather than a CNS-mediated motor sign. Mydriasis can occur with a range of sympathetic or anticholinergic factors and isn’t specific to MAOIs. Ptosis points to a possible cranial nerve or neuromuscular issue. The mnemonic association specifically highlights nystagmus as the ocular sign most characteristic of MAOI exposure.