Which is a common adverse effect of prostaglandin analogs used in glaucoma?

• A. Iris heterochromia
• B. Decreased tear production
• C. Bone marrow suppression
• D. Photosensitivity

Answer: (A)

Prostaglandin analogs often cause a pigment change in the iris because they stimulate melanin production in the iris stroma. This leads to darkening of the iris over time, which is especially noticeable in lighter-colored irises and can produce iris heterochromia. It’s a cosmetic change that can be permanent with continued therapy, but it doesn’t affect vision.

The other options don’t match this common effect: tearing or tear production isn’t typically reduced by these meds, bone marrow suppression isn’t a risk with topical glaucoma drugs, and photosensitivity isn’t a typical adverse effect of prostaglandin analogs.