Which drug covers both gram-positive and gram-negative bacteria, as indicated by Polytrim?

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Study for the NBEO Part II TMOD Exam. Prepare with flashcards and multiple choice questions, each with hints and explanations. Get ready for your exam!

Multiple Choice

Which drug covers both gram-positive and gram-negative bacteria, as indicated by Polytrim?

Explanation:
Two drugs with complementary spectra provide broad coverage against both gram-positive and gram-negative bacteria. Polymyxin B targets and disrupts the outer membrane of gram-negative bacteria, while trimethoprim inhibits bacterial folate synthesis and is active against many gram-positive organisms and some gram-negatives. When combined as Polytrim, these agents cover a wide range of pathogens that can cause conjunctivitis. Therefore, trimethoprim (Polytrim) is the drug that covers both gram-positive and gram-negative bacteria.

Two drugs with complementary spectra provide broad coverage against both gram-positive and gram-negative bacteria. Polymyxin B targets and disrupts the outer membrane of gram-negative bacteria, while trimethoprim inhibits bacterial folate synthesis and is active against many gram-positive organisms and some gram-negatives. When combined as Polytrim, these agents cover a wide range of pathogens that can cause conjunctivitis. Therefore, trimethoprim (Polytrim) is the drug that covers both gram-positive and gram-negative bacteria.

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