Which agent class increases uveoscleral outflow and decreases aqueous production?

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Study for the NBEO Part II TMOD Exam. Prepare with flashcards and multiple choice questions, each with hints and explanations. Get ready for your exam!

Multiple Choice

Which agent class increases uveoscleral outflow and decreases aqueous production?

Explanation:
Drugs that both decrease aqueous production and increase uveoscleral outflow are alpha2-adrenergic agonists. They act on alpha2 receptors in the ciliary body to lower cAMP, reducing aqueous humor production, and they can also promote drainage through the uveoscleral pathway, partly by relaxing the ciliary muscle or altering outflow pathways. Clinically, brimonidine and apraclonidine are classic examples. Prostaglandins mainly boost uveoscleral outflow without reducing production; beta blockers reduce production with little effect on outflow; pilocarpine increases trabecular outflow and does not decrease production.

Drugs that both decrease aqueous production and increase uveoscleral outflow are alpha2-adrenergic agonists. They act on alpha2 receptors in the ciliary body to lower cAMP, reducing aqueous humor production, and they can also promote drainage through the uveoscleral pathway, partly by relaxing the ciliary muscle or altering outflow pathways. Clinically, brimonidine and apraclonidine are classic examples. Prostaglandins mainly boost uveoscleral outflow without reducing production; beta blockers reduce production with little effect on outflow; pilocarpine increases trabecular outflow and does not decrease production.

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