What is the recommended dosing time for prostaglandin analogs in glaucoma management?

• A. Morning dosing
• B. Bedtime
• C. Twice daily
• D. Weekly dosing

Answer: (B)

Prostaglandin analogs lower IOP by increasing uveoscleral outflow and are best given as a single daily dose in the evening. The effect lasts about 24 hours, with the greatest reduction often occurring during the early morning hours when IOP tends to rise. Dosing at bedtime ensures stable 24-hour control and aligns the peak effect with the body’s circadian IOP pattern, while also supporting good adherence because it fits a consistent daily routine. Morning dosing can still lower IOP but tends to provide slightly less consistent 24-hour coverage; twice daily dosing offers no added benefit and increases exposure and potential side effects; weekly dosing would not achieve adequate IOP reduction.