Tetracyclines are contraindicated in which groups?

• A. Children
• B. Pregnant or lactating women
• C. Elderly
• D. Both Children and Pregnant or lactating women

Answer: (D)

Tetracyclines bind calcium and become incorporated into mineralizing tissues, so they affect developing teeth and bones. In children, this can cause permanent tooth discoloration and enamel hypoplasia; in the fetus, these drugs cross the placenta and can deposit in developing teeth and bones, potentially impacting fetal development. They’re also excreted in breast milk, which can affect a nursing infant. For these reasons, tetracyclines are avoided in children and in pregnant or lactating women. Age alone in the elderly isn’t a contraindication; the decision rests on weighing benefits and risks, with attention to other adverse effects like photosensitivity and GI upset.