Isotretinoin (Accutane) has been associated with which ocular complication?

• A. Papilledema
• B. Keratoconus
• C. Retinal detachment
• D. Cataracts

Answer: (C)

Isotretinoin can affect the eye in several ways, and while most patients experience dryness and irritation, there are rare reports of retinal complications during treatment. Retinal detachment has been described in association with isotretinoin, which is why this option is the best match among the choices.

Keratoconus involves the cornea’s shape and isn’t typically linked to isotretinoin. Cataracts affect the lens and are not a common site of isotretinoin-related change. Papilledema would indicate raised intracranial pressure, which is not a typical direct effect of isotretinoin (though very rarely intracranial hypertension has been discussed, it doesn’t present as the classic retinal detachment complication described here).