Doxycycline is commonly used in which ocular condition due to anti-inflammatory effects?

• A. Allergic Conjunctivitis
• B. Dry Eye with Meibomian Gland Dysfunction
• C. Acute Bacterial Keratitis
• D. Viral Conjunctivitis

Answer: (B)

Doxycycline’s anti-inflammatory effects are especially helpful in lid and meibomian gland disease, where inflammation around the eyelids and altered meibum contribute to evaporative dry eye. At low doses, it inhibits inflammatory enzymes like matrix metalloproteinases and reduces proinflammatory mediators, while also reducing bacterial lipase activity that can worsen meibum quality. This combination improves meibomian gland function and tear film stability, making it a common choice for dry eye associated with Meibomian Gland Dysfunction. It isn’t the primary therapy for allergic conjunctivitis, acute bacterial keratitis, or viral conjunctivitis, where antihistamines/mast cell stabilizers, topical antibiotics, or antivirals/supportive care are used instead.