Anterior subcapsular lens deposits are associated with which medication?

• A. Prednisone
• B. Acetazolamide
• C. Amiodarone
• D. Latanoprost

Answer: (C)

Medications can produce characteristic lens changes, and amiodarone is one of the drugs most associated with anterior subcapsular lens opacities. Amiodarone is highly lipophilic and accumulates in ocular tissues, so it can cause deposits in the cornea (even seen as corneal verticillata) and in the lens. When deposition occurs beneath the anterior capsule, it presents as anterior subcapsular opacities that can affect vision, especially with longer treatment or higher cumulative doses. This pattern differentiates it from other drugs listed—steroid-induced cataracts are typically posterior subcapsular, acetazolamide isn’t classically linked to anterior subcapsular deposits, and latanoprost’s notable ocular effects are different (iris changes, eyelash growth, CME in some cases) rather than anterior subcapsular lens opacities.